张兰,女,药理学博士,医院药事管理硕士,首都医科大学宣武医院药物研究室主任,研究员,研究生导师。
长期从事“药物防治老年神经退行性疾病的药理学研究与新药开发”和“老年人合理用药”研究。
北京市高层次卫生技术人才-学科带头人,北京市科技新星,新世纪百千万人才工程北京市级人选。
现任中国老年保健医学研究会老年合理用药分会副主任委员兼秘书长,北京药理学会副理事长兼秘书长,中国药理学会理事,中国中西医结合学会实验医学专业委员会常务委员,中国药学会老年药学专业委员会委员,中国老年学学会衰老与抗衰老科学委员会理事。担任Restorative Neurology and Neuroscience、Journal of Alzheimer’s disease编委等职。作为负责人承担国家级和省部级课题22项,获北京市科学技术一等奖1项,国家科学技术进步二等奖1项。获新药发明专利授权11项。已在国内外期刊上发表论著100余篇,SCI论文40余篇。
 
篇代表性论文 
? Lan Zhang*, Cong Shen, Jin Chu, Ying Liu, Yali Li, Li Zhang, Lin Li*. Icariin reduces ?-synuclein over-expression by promoting ?-synuclein degradation. AGE, 2015,37(4): 9811.  DOI 10.1007/s11357-015-9811-z
? Lan Zhang, Cong Shen, Jin Chu, Ruyi Zhang, Yali Li, Lin Li*. Icariin decreases the expression of APP and BACE-1 and reduces the ?-amyloid burden in an APP transgenic mouse model of Alzheimer’s disease. International Journal of Biological Sciences, 2014, 10(2):181-191. doi: 10.7150/ijbs.6232
? Lan Zhang*, Shun Yu, Ruyi Zhang, Ying Xing, Yaohua Li, Lin Li*. Tetrahydroxystilbene glucoside antagonizes age-related ?-synuclein overexpression in the hippocampus of APP transgenic mouse model of Alzheimer’s disease. Restorative Neurology and Neuroscience, 2013, 31:41-52 
? Cui-cui Yang, Xue-xian Kuai, Ya-li Li, Li Zhang, Jian-chun Yu, Lin Li*, Lan Zhang*. Cornel iridoid glycoside attenuates tau hyperphosphorylation by inhibition of PP2A demethylation. Evidence-based Complementary and Alternative Medicine, 2013, 2013:108486. doi:10.1155/2013/108486  2013,1-9
? Cui-cui Yang, Lin Li, Sha-sha Zheng, Jie Lu, Li Zhang, Ya-li Li, Lan Zhang*. Cornel iridoid glycoside reduces infarct size measured by magnetic resonance imaging and improves neurological function after focal cerebral ischemia in rats. Chin J Integr Med. 2015 Aug 11. doi:10.1007/s11655-015-2288-x
 
研究方向
长期进行“中药防治老年神经退行性疾病的药理学研究与新药开发”,对以山茱萸、何首乌、淫羊藿为代表的补肾中药及其有效成分,进行了系统、深入的筛选与研究。在神经精神药理学领域、尤其是在抗老年痴呆药物研究方面取得较为领先的成就,得到学术界的一致认可。近5年以来,作为课题负责人承担各级项目16项,其中四项国家级课题,四项省部级课题,八项局级及其他课题,经费逾600万元。发表论文70余篇,第一作者及通讯作者论文30余篇,其中SCI收录论文12篇(累计影响因子27.39,2015最新影响因子)。
 
所获奖项和荣誉
? 北京市科学技术一等奖,2005年。完成人:李林、张兰、赵玲、安文林、王文、魏海峰、李斌、贾建平、张如意、叶翠飞、楚晋、张丽。补肾中药治疗老年性痴呆的实验研究与技术平台的建立。主要完成单位:首都医科大学宣武医院。(2005中-1-001) 
? 国家科学技术进步二等奖,2013年。获奖人:贾建平、李林、盛树力、王蓉、贺永、孙秀莲、汤哲、张兰、王芬、魏翠柏。项目名称:痴呆与轻度认知障碍的流行病学、发病机制和诊治应用研究。证书号码:2013-J-23301-2-02
? 北京市高层次卫生技术人才-学科带头人,北京市科技新星,新世纪百千万人才工程北京市级人选。
 
近五年发表论文(第一及通讯作者)
1. Zhang L*, Shen C, Chu J, Liu Y, Li YL, Zhang L, Li L*. Icariin reduces ?-synuclein over-expression by promoting ?-synuclein degradation. AGE, 2015, 37(4): 9811. Doi: 10.1007/s11357-015-9811-z 
2. Cui-cui Yang, Lin Li, Sha-sha Zheng, Jie Lu, Li Zhang, Ya-li Li, Lan Zhang*. Cornel iridoid glycoside reduces infarct size measured by magnetic resonance imaging and improves neurological function after focal cerebral ischemia in rats. Chin J Integr Med. 2015 Aug 11. doi:10.1007/s11655-015-2288-x [Epub ahead of print]
3. Cong Shen, Fang-ling Sun, Ru-yi Zhang, Lan Zhang*, Lin Li*. Tetrahydroxystilbene glucoside ameliorates memory and movement functions, protects synapses and inhibits α-synuclein aggregation in hippocampus and striatum in aged mice. Restorative Neurology and Neuroscience, 2015,33(4): 531-541.
4. Lan Zhang, Cong Shen, Jin Chu, Ruyi Zhang, Yali Li, Lin Li*. Icariin decreases the expression of APP and BACE-1 and reduces the ?-amyloid burden in an APP transgenic mouse model of Alzheimer’s Disease. International Journal of Biological Sciences. 2014,10(2):181-191
5. Lan Zhang, Shun Yu, Ruyi Zhang,Ying Xing, Yaohua Li, Lin Li*. Tetrahydroxystilbene glucoside antagonizes age-related α-synuclein overexpression in the hippocampus of APP transgenic mouse model of Alzheimer's disease. Restorative Neurology and Neuroscience. 2013, 31(1): 41-52
6. Lan Zhang, Hui Ding, Dan-Hui Wang, Yan-Li Zhang, Andrius Baskys, Piu Chan, Yu Zhong, Yan-Ning Cai*. Calpastatin gene (CAST) is not associated with late onset sporadic Parkinson’s disease in the Han Chinese population. PLoS ONE. 2013, 8(8):e70935. DOI:10.1371/journal.pone.0070935 
7. Lan Zhang, Bailiu Ya, Pan Yang, Fangling Sun, Li Zhang, Yali Li, Lin Li*. Impact of carotid atherosclerosis combined with hypercholesterolemia on cerebral microvessles and brain parenchyma in a new complex rat model. Neurochem Res, 2014, 39:653–660. DOI: 10.1007/s11064-014-1242-1 
8. Cui-cui Yang, Xue-xian Kuai, Ya-li Li, Li Zhang, Jian-chu Yu, Lin Li*, Lan Zhang*. Cornel iridoid glycoside attenuates tau phosphorylation by inhibition of PP2A demethylation. Evidence-based Complementary and Alternative Medicine. 2013, 2013:108486. 
9. Lan Zhang, Qingling Lin, Hui Ding, Danhui Wang, Yanning Cai*. Promoter methylation of seven clock genes in total leukocytes from different-aged healthy subjects. Biological Rhythm Research. 2012,43(6): 631–637
10. Lan Zhang, Qin-gling Lin, Lu Lu, Cui-cui Yang, Ya-Li Li, Fangling Sun, Yanning Cai*, Lin Li*. Tissue-specific modification of clock methylation in aging mice. European Review for Medical and Pharmacological Sciences, 2013, 17 (14): 1874-1880 
11. Yang Yu; Lan Zhang#(共同第一作者); Xiaojing Li; Xiaoqin Run; Zhihou Liang; Yi Li; Ying Liu; Moon Lee; Inge Grundke-Iqbal; Khalid Iqbal; David Vocadlo; Fei Liu; Cheng-Xin Gong*. Differential Effects of an O-GlcNAcase Inhibitor on Tau Phosphorylation. PLoS ONE, 2012, 7(4): e35277. 
12. Bailiu Ya, Lan Zhang#(共同第一作者); Li Zhang, Yali Li, Lin Li* . 5-hydroxymethyl-2-furfural prolongs survival and inhibits oxidative stress in a mouse model of forebrain Ischemia. Neural Regeneration Research, 2012,7(22):1722-1728 
13. Cui-cui Yang#, Xue-xian Kuai,#, Wen-bin Gao, Jian-chun Yu, Qi Wang, Lin Li, Lan Zhang*. Morroniside-induced PP2A activation antagonizes tau hyperphosphorylation in a cellular model of neurodegeneration. JAD,2016,In press. 
1. 包训杰,蔡彦宁,祝艳秋,杨翠翠,李林,张兰*。3xTg-拟AD小鼠脑内七种时钟基因启动子区甲基化分析。首都医科大学学报,2015,36(6)875-881(通讯作者)
2. 陈晨,张兰*。Tau蛋白相关的抗阿尔茨海默病药物研究进展。神经疾病与精神卫生,2015,15(5):459-462(通讯作者)
3. 祝艳秋,张兰*。基于3xTg-拟AD小鼠模型的药理学研究进展。中国比较医学杂志,2015,21(1):61-66(通讯作者)
4. 祝艳秋,陆璐,李林,蔡彦宁,张兰*。时钟基因启动子甲基化频率随增龄的组织特异性改变。中国康复理论与实践,2015,21(5):514-518(通讯作者)
5. 陆璐,蔡彦宁,张兰*。小鼠α-synuclein内含子1甲基化定量检测方法的建立及不同脑区甲基化水平的比较研究中国比较医学杂志,2014,24(4):45-49(通讯作者)
6. 郐学先,于建春,张兰*。以微管相关蛋白Tau为靶点的抗阿尔茨海默病药物研究进展。中国康复理论与实践。 2014,20(3):240-244 (通讯作者)
7. 褚思娟,李林,张兰*. 山茱萸环烯醚萜苷主要药理作用研究进展.中国医药. 2013, 8(4):568-570 (通讯作者)
8. 杨翠翠,李林,张兰*. Tau 蛋白高度磷酸化致阿尔茨海默病动物模型研究进展。中国比较医学杂志,2013,23(6):71-74.  (通讯作者)
9. 杨翠翠,李林,张兰*.常用阿尔茨海默病动物模型制备方法及评价。成都医学院学报. 2013, 8(4):374-378     (通讯作者)
10. 张兰,张如意,李雅莉,张丽,叶翠飞,李林*。参乌胶囊对微泵恒速灌注叠氮钠致痴呆大鼠行为学及胆碱能系统的影响。中国中药杂志,2013, 38(9):1300-1305
11. 张兰,贾丹,闫素英,王育琴,李林*。临床药理学双语教学示范课程建设。中国医药,2013 ,8(7):1023-1024
12. 刘莹,李林,张兰*。二苯乙烯苷对基因转染PC12细胞?-突触核蛋白过表达和泛素-蛋白酶体系统的影响。中国药学杂志, 2012, 47(1):34-39. (通讯作者)
13. 李延峥,李林,张兰*. 快速老化小鼠SAMP8 在阿尔茨海默病研究中的应用. 中国康复理论与实践, 2012, 18(12):1119-1122 (通讯作者)
14. 张兰,刘芳,万岁桂,贾建平,李林。阿尔茨海默病转线粒体DNA细胞模型胞浆钙稳态的改变。首都医科大学学报,2011,32(1):67-72
 
专著:
谢惠民、李林,主编;张兰,副主编. 老年人合理用药和延缓衰老药物 第2版。人民卫生出版社 ISBN 978-7-117-15257-0/R.15258,2012.
 

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